Twenty most significant publications

Nora E.P., Lajoie B., Schulz E.G., Giorgetti L., Okamoto I., Servant N. Piolot T., van Berkum  N.L., Meisig  J., Sedat J., Barillot E., Blüthgen N., Dekker J.* and Heard E*. Spatial partitioning of the regulatory landscape of the X-inactivation center. Nature 485:381-5. (*co-corresponding authors)

Masui O., Bonnet I., Le Baccon P., Brito I., Pollex T., Murphy N., Hupé P., Barillot E., Belmont A. and Heard E. (2011) Live cell chromosome dynamics and outcome of X-chromosome pairing events during ES cell differentiation. Cell 145: 447-458.

Okamoto I., Patrat C., Thepot D., Peynot N., Diabangouya P., Fauque P., Daniel N., Wolf JP., Renard JP., Duranthon V.* and Heard E*. (2011) Evolutionary Diversity of X-chromosome Inactivation in Mammals. Nature 472: 370-374. (*co-corresponding authors)

Augui S., Nora E. and Heard E. (2011) Regulation of X-chromosome inactivation by the X-inactivation centre. Nature Reviews Genetics 12: 429-442.

Chow J., Ciaudo C., Fazzari M., Mise N., Servant N., Glass J.L., Attreed M., Avner P., Wutz A., Barillot E., Greally J.M., Voinnet O., Heard E. (2010) LINE1 activity in facultative heterochromatin formation during X-chromosome inactivation. Cell 141: 956–969.

Heard E., Tishkoff S, Todd JA, Vidal M, Wagner GP, Wang J, Weigel D, Young R. (2010) Ten years of genetics and genomics: what have we achieved and where are we heading. Nature Reviews Genetics 11: 723-733.

Patrat C., Okamoto I., Diabangouya P., Vialon V., Le Baccon P., Chow J. and Heard E. (2009) Dynamic changes in paternal X-chromosome activity during imprinted X inactivation in mice Proc Natl Acad Sci USA. 106: 5198-5203.

Augui S., Filion G., Huart S., Guggiari M., Maresca M., Stewart F. and Heard E. (2007) Sensing X-chromosome pairs prior to X inactivation via a novel X-pairing region of the Xic. Science 318, 1632-1636. (Faculty of 1000: 6.4 Must Read)

Vincent-Salomon A.*, Ganem-Elbaz C.*, Manié E.*, Raynal V., Sastre-Garou X., Stoppa-Lyonnet D., Stern M-H. and Heard E. (2007) XIST RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors. Cancer Research 67: 5134-5140 (*equal contribution)

Chaumeil J., Le Baccon P., Wutz A. and Heard E. (2006) A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced. Genes and Development 20: 2223-2237. (Faculty of 1000: 4.8  Must Read)

Bacher C., Guggiari M., Brors B., Augui S., Avner P., Eils R. and Heard E. (2006) Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nature Cell Biology 8: 293-239.

Okamoto I., Arnaud D., Otte AP, Disteche C., Avner P. and Heard E. (2005) Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice.  Nature 438: 369-373. (Faculty of 1000: 6.0 Must Read)

Okamoto I., Otte A., Allis C.D., Reinberg D. and Heard E. (2004) Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303: 644-649. (Faculty of 1000: 6.0 Must Read)

Narita M., Nunez S., Heard E., Narita M., Lin A.W., Hearn S.A., Spector D.L., Hannon G. J. and Lowe S.W. (2003) Rb-Mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell, 113: 703-716. (Faculty of 1000: 3.0 Recommended)

Boggs B. A., Cheung P., Heard E., Spector D. L., Chinault C.A. and Allis C.D. (2002) Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nature Genetics 30: 73-76. (Faculty of 1000: 9.0 Exceptional)

Avner P. and Heard E. (2001) X-chromosome inactivation: counting, choice and initiation. Nature Rev. Genetics 2: 59-67.

Heard E., Rougeulle C., Arnaud D., Avner P., Allis C. D. and Spector D. L. (2001) Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X-inactivation. Cell 107: 727-738. (Faculty of 1000 : 4.9  Must Read)

Heard E., Mongelard F., Arnaud D., Avner P. (1999a) Xist YAC transgenes function as Xics only in multicopy arrays and not as single copies. Mol. Cell. Biol. 19: 3156-66.

Heard E., Mongelard F., Arnaud D., Chureau C., Vourc’h C. and Avner P. (1999b) Human XIST YAC transgenes show partial XIC function in mouse ES cells. Proc. Natl. Acad. Sci. USA, 96: 6841-6.

Heard E., Clerc P. and Avner P. (1997) X chromosome inactivation in mammals. Annual Review of Genetics 31: 571-610.