Principales publications

  • Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, Léveillard “T. Rod-derived Cone Viability Factor acts by stimulating aerobic glycolysis”. Cell, 2015 May 7;161(4):817-32.
  • Schmitz-Valckenberg S, Sahel JA, Danis R, Fleckenstein M, Jaffe GJ, Wolf S, Pruente C, Holz FG. “Natural History of Geographic Atrophy Progression Secondary to Age-Related Macular Degeneration (Geographic Atrophy Progression Study)”. Ophthalmology. 2015 Nov 3. [Epub ahead of print]
  • Macé E, Caplette R, Marre O, Sengupta A, Chaffiol A, Barbe P, Desrosiers M, Bamberg E, Sahel JA, Picaud S, Duebel J, Dalkara D. “Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice”. Mol Ther. 2015 Jan;23(1):7-16.
  • Berger A, Lorain S, Joséphine C, Desrosiers M, Peccate C, Voit T, Garcia L, Sahel JA, Bemelmans AP. “Repair of rhodopsin mRNA by spliceosome-mediated RNA trans-splicing: a new approach for autosomal dominant retinitis pigmentosa”. Mol Ther. 015 May;23(5):918-30.
  • Byrne LC, Dalkara D, Luna G, Fisher SK, Clérin E, Sahel JA, Léveillard T, Flannery JG. “Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration”. J Clin Invest. 2015 Jan;125(1):105-16.
  • Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot EF, Sahel JA, Monville C, Goureau O. “From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium”. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8518-23.
  • Sahel JA, Roska B. “Gene therapy for blindness”. Ann Rev Neurosci 2013, Jul 8;36:467-88.
  • Jaillard C, Mouret A, Niepon ML, Clérin E, Yang Y, Lee-Rivera I, Aït-Ali N, Millet-Puel G, Cronin T, Sedmak T, Raffelsberger W, Kinzel B, Trembleau A, Poch O, Bennett J, Wolfrum U, Lledo PM, Sahel JA, Léveillard T. “Nxnl2 splicing results in dual functions in neuronal cell survival and maintenance of cell integrity”. Hum Mol Genet. 2012 May 15;21(10):2298-311.
  • Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Sahel JA, Stanga PE, Cideciyan AV, Duncan JL, Eliott D, Filley E, Ho AC, Santos A, Safran AB, Arditi A, Del Priore LV, Greenberg RJ; Argus II Study Group. “Interim results from the international trial of Second Sight's visual prosthesis”. Ophthalmology. 2012 Apr;119(4):779-88.
  • Lorach H, Benosman R, Marre O, Ieng SH, Sahel JA, Picaud S. “Artificial retina: the multichannel processing of the mammalian retina achieved with a neuromorphic asynchronous light acquisition device”. J Neural Eng. 2012 Dec;9(6):066004.
  • Bouaita A, Augustin S, Lechauve C, Cwerman-Thibault H, Bénit P, Simonutti M, Paques M, Rustin P, Sahel JA, Corral-Debrinski “M. Downregulation of apoptosis-inducing factor in Harlequin mice induces progressive and severe optic atrophy which is durably prevented by AAV2-AIF1 gene therapy”. Brain. 2012 Jan;135(Pt 1):35-52.
  • Vignal-Clermont C, Audo I, Sahel JA, Paques M. “Poppers-associated retinal toxicity”. N Engl J Med. 2010 Oct 14;363(16):1583-5.
  • Paques M, Simonutti M, Augustin S, Goupille O, El Mathari B, Sahel JA. “In vivo observation of the locomotion of microglial cells in the retina”. Glia. 2010 Nov 1;58(14):1663-8.
  • Busskamp V, Duebel J, Balya D, Fradot M, Viney TJ, Siegert S, Groner AC, Cabuy E, Forster V, Seeliger M, Biel M, Humphries P, Paques M, Mohand-Said S, Trono D, Deisseroth K, Sahel JA, Picaud S, Roska B. “Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis pigmentosa”. Science. 2010 329(5990):413-7.
  • Léveillard T, Sahel JA. “Rod-derived cone viability factor for treating blinding diseases: from clinic to redox signaling”. Sci Transl Med. 2010 Apr 7;2(26):26ps16.
  • Yang Y, Mohand-Said S, Danan A, Simonutti M, Fontaine V, Clerin E, Picaud S, Léveillard T, Sahel JA. “Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosa”. Mol Ther. 2009 May;17(5):787-95.
  • Léveillard T, Mohand-Saïd S, Lorentz O, Hicks D, Fintz AC, Clérin E, Simonutti M, Forster V, Cavusoglu N, Chalmel F, Dollé P, Poch O, Lambrou G, Sahel JA. “Identification and characterization of rod-derived cone viability factor”. Nat Genet. 2004 Jul;36(7):755-9.
  • Porto FB, Perrault I, Hicks D, Rozet JM, Hanoteau N, Hanein S, Kaplan J, Sahel JA. “Prenatal human ocular degeneration occurs in Leber's congenital amaurosis (LCA2)”. J Gene Med. 2002 Jul-Aug;4(4):390-6.
  • Frasson M, Sahel JA, Fabre M, Simonutti M, Dreyfus H, Picaud S. “Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse”. Nat Med. 1999 Oct;5(10):1183-7.
  • Mohand-Said S, Deudon-Combe A, Hicks D, Simonutti M, Forster V, Fintz AC, Léveillard T, Dreyfus H, Sahel JA. “Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse”. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8357-62.