Therapeutic Innovations: What Strategies Can Stimulate the Development of New Drugs?

Protein-protein interactions are involved in many cellular processes and in their dysfunction, suggesting that they could be valuable therapeutic targets (between 100,000 and 600,000 interactions in humans, not mentioning interactions with proteins of microorganisms...). However, the design of small chemical compounds orally available that could modulate such interactions is difficult and requires the development of specific tools and the development of novel concepts.

Recent successes highlight some key structural properties of protein-protein interfaces, suggesting that it should be possible to modulate these interactions with small chemical compounds, as well as a specific profile for these small molecules. In this presentation, after a short introduction, we will discuss new bio- and chemoinformatics strategies that should assist the rational design of bioactive molecules acting on protein-protein interactions.