Salmonelle: From Diarrhea to Typhoid Fever

Salmonella interacts extensively with several host cells and tissues, as well as the intestinal microbiome during the infectious process. Systemic salmonellosis (typhoid-like) has been extensively characterized, but only recently have murine models that produce gastroenteritis been developed. Using a variety of murine models, we have been studying various aspects of salmonellosis. These include development of a new chronic model of fibrosis induced by Salmonella in a chronic infection model. We have also been studying how Salmonella reside within the gall bladder epithelium, a process essential for carriage and shedding in bile associated with spread of typhoid fever, yet very poorly characterized. We have also been examining the effect of Salmonella on the microbiota, and how this contributes to intestinal colonization and gastroenteritis. Various aspects of these interactions will be discussed in light of their contribution to salmonellosis.