Articles de recherche

  • Quintana-Murci, L., Semino, O., Bandelt, H.J., Passarino, G., McElreavey, K. & Santachiara-Benerecetti, A.S. (1999) Genetic evidence of an early exit of Homo sapiens sapiens from Africa through eastern Africa. Nature Genetics 23, 437-441.
  • Barreiro, L.B., Laval, G., Quach, H., Patin, E. & Quintana-Murci, L. (2008) Natural selection has driven population differentiation in modern humans. Nature Genetics 40, 340-345.
  • Louicharoen C, Patin E, Paul R, Nuchprayoon I, Witoonpanich B, Peerapittayamongkol C, Casademont I, Sura T, Laird NM, Singhasivanon P, Quintana-Murci L, Sakuntabhai A (2009). Positively Selected G6PD-Mahidol Mutation Reduces Plasmodium vivax Density in Southeast Asians. Science 326(5959):1546-9
  • Manry J, Laval G, Patin E, Fornarino S, Itan Y, Fumagalli M, Sironi M, Tichit M, Bouchier C, Casanova JL, Barreiro LB, Quintana-Murci L (2011) Evolutionary genetic dissection of human interferons. Journal of Experimental Medicine 208(13):2747-59.
  • Vasseur E, Boniotto M, Patin E, Laval G, Quach H, Manry J, Crouau-Roy B, Quintana-Murci L. (2012) The Evolutionary Landscape of Cytosolic Microbial Sensors in Humans. American Journal of Human Genetics 91(1):27-37.
  • Patin E, Siddle KJ, Laval G, Quach H, Harmant C, Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L (2014) The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists. Nature Communications 5:3163.
  • Siddle KJ, Deschamps M, Tailleux L, Nedelec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci L (2014) A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection. Genome Research 24(5):850-9.
  • Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci L (2015) The epigenomic landscape of African rainforest hunter-gatherers and farmers. Nature Communications 6:10047
  • Quach H, Rotival M, Pothlichet J, Loh YE, Dannemann M, Zidane N, Laval G, Patin E, Harmant C, Lopez M, Deschamps M, Naffakh N, Duffy D, Coen A, Leroux-Roels G, Clément F, Boland A, Deleuze JF, Kelso J, Albert ML, Quintana-Murci L (2016) Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations. Cell 167(3):643-656
  • Deschamps M, Laval G, Fagny M, Itan Y, Abel L, Casanova JL, Patin E, Quintana-Murci L. (2016) Genomic Signatures of Selective Pressures and Introgression from Archaic Hominins at Human Innate Immunity Genes. American Journal of Human Genetics 98(1):5-21.
  • Patin E, Lopez M, Grollemund R, Verdu P, Harmant C, Quach H, Laval G, Perry GH, Barreiro LB, Froment A, Heyer E, Massougbodji A, Fortes-Lima C, Migot-Nabias F, Bellis G, Dugoujon JM, Pereira JB, Fernandes V, Pereira L, Van der Veen L, Mouguiama-Daouda P, Bustamante CD, Hombert JM, Quintana-Murci L (2017) Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America. Science 356: 543–546.
  • Lopez M, Kousathanas A, Quach H, Harmant C, Mouguiama-Daouda P, Hombert JM, Froment A, Perry GH, Barreiro LB, Verdu P, Patin E, Quintana-Murci L (2018) The demographic history and mutational load of African hunter-gatherers and farmers. Nature Ecology and Evolution 2(4):721-730
  • Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L & the Milieu Intérieur Consortium (2018). Distinctive Roles of Age, Sex and Genetics in Shaping Transcriptional Variation of Human Immune Responses to Microbial Challenges. Proceeding of the National Academy USA 115(3):E488-E497
  • Patin E, Hasan M, Bergstedt J, Rouilly V, Libri V, Urrutia A, Alanio C, Scepanovic P, Hammer C, Jönsson F, Beitz B, Quach H, Wearn Lim Y, Hunkapiller J, Zepeda M, Green C, Piasecka B, Leloup C, Rogge L, Huetz F, Peguillet I, Lantz O, Fontes M, Di Santo Jp, Thomas S, Fellay J, Duffy D, Quintana-Murci L, Albert Ml & the Milieu Intérieur Consortium (2018). Natural variation in innate immune cell parameters is primarily driven by genetic factors. Nature Immunology 19(3):302-314
  • Rotival M, Quach H, Quintana-Murci L (2019). Defining the genetic and evolutionary architecture of alternative splicing in response to infection. Nature Communications. 2019 Apr 11;10(1):1671
  • Laval G, Peyrégne S, Zidane N, Harmant C, Renaud F, Patin E, Prugnolle F, Quintana-Murci L (2019) Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria Exposure. American Journal of Human Genetics 104(3):553-561.

Revues de synthèse

  • Quintana-Murci, L., Alcais, A., Abel, L. and Casanova, J. L. (2007). Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases. Nature Immunology 8(11):1165-1171.
  • Barreiro LB, Quintana-Murci L (2010) From evolutionary genetics to human immunology: how selection shapes host defence genes. Nature Reviews Genetics 11(1):17-30
  • Quintana-Murci L, Clark AG. (2013) Population genetic tools for dissecting innate immunity in humans. Nature Reviews Immunology 13(4):280-93.
  • Casanova JL, Abel L, Quintana-Murci L (2013) Immunology taught by human genetics. Cold Spring Harbor Symposia on Quantitative Biology 78:157-72
  • Quintana-Murci L (2016) Understanding rare and common diseases in the context of human evolution. Genome Biology 17(1):225
  • Quach H, Quintana-Murci L (2017) Living in an adaptive world: Genomic dissection of the genus Homo and its immune response. Journal of Experimental Medicine 214(4):877-894
  • Patin E, Quintana-Murci L (2018) The demographic and adaptive history of central African hunter-gatherers and farmers. Current Opinion in Genetics and Development 53:90-97.
  • Quintana-Murci L (2019) Human Immunology through the Lens of Evolutionary Genetics. Cell 177(1):184-199