Principales publications

• The bulk of the peripheral B cell pool in mice is stable and not rapidly renewed from the bone marrow

  Förster I. et Rajewsky K., « The bulk of the peripheral B cell pool in mice is stable and not rapidly renewed from the bone marrow », Proc. Natl. Acad. Sci. USA, n° 87, 1990, p. 4781-4784.

• Maintenance of B cell memory by long-lived cells generated from proliferating precursors

  Schittek B. et Rajewsky K., « Maintenance of B cell memory by long-lived cells generated from proliferating precursors », Nature, n° 346, 1990, p. 749-751.

• Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly 1 B cell and B-CLL progenitor generation

  Gu H., I. Förster I. et Rajewsky K., « Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly 1 B cell and B-CLL progenitor generation », EMBO J., n° 9, 1990, p. 2133-2140.

• Analysis of the B cell progenitor compartment at the level of single cells

  Ehlich A., Martin V., Müller W. et Rajewsky K., « Analysis of the B cell progenitor compartment at the level of single cells », Curr. Biol., n° 4, 1994, p. 573-583.

• Interclonal generation of antibody mutants in germinal centers

  Jacob J., Kelsoe G., Rajewsky K. et Weiss U., « Interclonal generation of antibody mutants in germinal centers », Nature, n° 354, 1991, p. 389-392.

• Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections

  Küppers R., Zhao M., Hansmann M.-L. et Rajewsky K., « Tracing B cell development in human germinal centers by molecular analysis of single cells picked from histological sections », EMBO J., n° 12, 1993, p. 4955-4967.

• Burkitt's lymphoma is a malignancy of nature B cells expressing somatically mutated V region genes

  Klein U., Klein G., Ehlin-Henriksson B., K. Rajewsky K. et Küppers R., « Burkitt's lymphoma is a malignancy of nature B cells expressing somatically mutated V region genes », Mol. Med., n° 1, 1995, p. 495-505.

• Hodgkin's disease : Hodgkin and Reed-Sternberg cells picked from histological sections show clonal Ig gene rearrangements and appear to be derived from B cells at various stages of development

  Küppers R., Rajewsky K., Zhao M., Simons G., Laumann R., Fischer R. et Hansmann M.-L., « Hodgkin's disease : Hodgkin and Reed-Sternberg cells picked from histological sections show clonal Ig gene rearrangements and appear to be derived from B cells at various stages of development », Proc. Nat. Acad., USA, n° 91, 1994, p. 10962-10966.

• Interleukin-10 deficient mice develop chronic entercolitis

  Kühn R., Löhler J., Rennick D., Rajewsky K. et Müller W., « Interleukin-10 deficient mice develop chronic entercolitis », Cell, n° 75, 1993, p. 263-274.

• A B cell deficient mouse generated through targeted disruption of the membrane exon of the immunoglobulin m chain

  Kitamura D., Roes J., Kühn R. et Rajewsky K., « A B cell deficient mouse generated through targeted disruption of the membrane exon of the immunoglobulin m chain », Nature, n° 350, 1991, p. 423-426.

• A critical role of 15 protein in B cell development

  Kitamura D., Kudo A., Schaal S., Müller W., Melchers F. et Rajewsky K., « A critical role of 15 protein in B cell development », Cell, n° 69, 1992, p. 823-831.

• Deletion of the immunoglobulin K chain intron enhancer abolishes K chain gene rearrangement in cis but not chain gene rearrangement in trans

  Takeda S., Zou Y., Bluethmann H., Kitamura D., Müller U. et Rajewsky K., « Deletion of the immunoglobulin K chain intron enhancer abolishes K chain gene rearrangement in cis but not chain gene rearrangement in trans », EMBO J., n° 12, 1993, p. 2329-2336.

• Impairment of T cell-dependant B-cell responses and B-1 cell development in CD19-deficient mice

  Rickert R.C., Rajewsky K. et Roes J., « Impairment of T cell-dependant B-cell responses and B-1 cell development in CD19-deficient mice », Nature, n° 376, 1995, p. 352-355.

• Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus

  Taki S., Meiering M. et Rajewsky K., « Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus », Science, n° 262, 1993, p. 1268-1271.

• ​ Cre-lox P- mediated gene replacement : a mouse strain producing humanized lgG1 antibodies ​

  Y. Zou, Müller W., Gu H. et Rajewsky K., « Cre-lox P- mediated gene replacement : a mouse strain producing humanized lgG1 antibodies », Curr. Biol., n° 4, 1994, p. 1099-1103.

• Deletion of a DNA polymerase B gene segment in T cells using cell type-specific gene targeting

  Gu H., Marth J. D., Orban P. C., Mossmann H. et Rajewsky K., « Deletion of a DNA polymerase B gene segment in T cells using cell type-specific gene targeting », Science, n° 265, 1994, p. 103-106.

• Inducible gene targeting in mice

  Kühn R., Schwenk F., Aguet M et Rajewsky K., « Inducible gene targeting in mice », Science, n° 269, 1995, p. 1427-1429.