Abstract
The depolymerization (i.e. progressive shortening) of large molecules can be modeled by discrete equations, such as Becker-Döring, or by continuous equations (Lifshitz-Slyozov). In many applications, the dynamic nature of the experiments, as well as their nanometric scale, makes it difficult to estimate quantitatively, or even simply to know, the mechanisms involved. Experiments carried out by Human Rezaei's team at INRAE on the depolymerization of PrP protein fibers, responsible for prion diseases, have revealed sustained oscillations that defy conventional mechanisms. The classical model was unable to account for this, so an oscillating model of depolymerization had to be devised and analyzed.
Work in collaboration with Klemens Fellner (Graz, Austria), Mathieu Mezache (INRAE), Human Rezaei (INRAE) and Juan Velázquez (Bonn, Germany).
