Dr. Emmanuelle Passegué, Ph.D. is the endowed Alumni Professor of Genetics & Development and the Director of the Columbia Stem Cell Initiative (CSCI) at Columbia University Irving Medical Center (CUIMC) in New York City. Dr. Passegué received her Ph.D. from the University Paris XI (France) and trained with Dr. Erwin Wagner (Institute for Molecular pathology, Vienna, Austria) and Dr. Irv Weissman (Stanford University, USA) before joining the University of California San Francisco (UCSF) in 2005. Dr. Passegué was a Professor of Medicine in the Hematology/Oncology Division and the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCSF until 2016 before joining Columbia University in January 2017. Her research investigates the biology of blood-forming hematopoietic stem cells in normal and deregulated contexts such as hematological malignancies and physiological aging. Dr. Passegué has received a number of awards and prizes including a Scholar Award from the Lymphoma and Leukemia Society, two consecutive Outstanding Investigator Awards from the NHLBI, the 2019 William Dameshek Prize from the American Society of Hematology (ASH), and the Donald Metcalf Award from the International Society of Experimental Hematology (ISEH).
The fundamental questions that drive Emmanuelle’s research on blood-forming hematopoietic stem cells (HSC) are how tissues sense and adapt to the ever-changing needs of the organism, and how corruption of such adaptive responses sets the stage for disease development and organismal aging. The goal of her laboratory is to identify affected genes and/or pathways that can be used to develop novel interventions using a variety of cross-disciplinary approaches in mouse models and human patient samples.
