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Dans la tradition chrétienne, la résurrection symbolise le dépassement de la mort et le triomphe d’une seconde vie de l’individu racheté pour toujours. La nouvelle religion salvatrice accorde également une grande importance à la reconnaissance que les …

Résumé The discovery of numerous and frequent mutations in epigenome modifers have highlighted the importance of epigenetic mechanisms in cancer. In addition, epimutations such as aberrant DNA met hylation have been reported to constitute the most …

Références Ng S.F., Lin R.C., Laybutt D.R., Barres R., Owens J.A., Morris M.J., "Chronic high-fat diet in fathers programs -celldysfunction in fernale rat offspring", Nature , 2010 Oct 21;467(7318):963-6 Rando O.J., "Daddy issues: paternal effects on …

Résumé Histone modifications can regulate many chromatin-related processes such as transcription, replication and DNA-repair, they can demarcate the genomic position of regulatory elements such as enhancers and may be involved in disease processes if …

Résumé Although the H19 gene was discovered in 1984, its precise function is still relatively poorly understood. lt is located on mouse chromosome 7, close to the Jg/2 (insulin-like growth factor 2) gene, in an imprinted locus. The maternal allele …

Résumé Germ cell differentiation allows the production of mature gametes that are competent for fertilization and that carry genetic but also non-genetically encoded information. DNA methylation is an autonomous epigenetic mark, with intrinsic stability …

Résumé Epigenetic regulation plays essential roles in development and disease and may become perturbed as a consequence of dietary and environ mental factors [1] . One of the best characterized epigenetic phenomena in ma mmals is genomic imprinting, a …

Résumé The majority of autosomal genes in mamma is are believed to be expressed from both alleles. However a number of imprinted genes exist and an increasing number of loci may be expressed monoallelically in a random fashion, similarly to the …

Résumé In mammals, the dosage imbalance between males and females resulting from the presence of heteromorphie sex chromosomes is compensated for by the inactivation of one X-chromosome in females. This process, which is initiated during the early …

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Résumé Environmental factors during early life are critical for the Jater metabolic health of the individual and of future progeny. Using a mouse model of maternal calorie restriction during pregnancy affecting the metabolic physiology of two generations …

Références Eustermann S., Yang J.C., Law M.J., Amos R., Chapman L.M., Jelinska C., Garrick D., Clynes D., Gibbons R.J., Rhodes D., Higgs D.R., Neuhaus D., "Combinatorial readout of histone H3 modifications specifies localization of ATRX to …

Résumé Position effect variegation (PEY) is an archetypal epigenetic phenomenon in which a gene abnormally located close to heterochromatin is stochastically silenced in a proportion of cells that would normally express it. First described in Drosophila …

Résumé Epigenetic regulation of cognition is an emerging field in Neuroscience. However, the identity of crucial regulators and underlying molecular mechanisms are poorly understood. Excellent candidates are epigenetic genes that are mutated in …

Cette intervention s'est déroulée à l'ENS. Documents et médias Accéder à l'audio …

Cette intervention s'est déroulée à l'ENS. Documents et médias Accéder à l'audio …

Cette intervention s'est déroulée à l'ENS Documents et médias Accéder à l'audio …

Cette intervention s'est déroulée à l'ENS. Documents et médias Accéder à l'audio …

Cette intervention s'est déroulée à l'ENS. Documents et médias Accéder à l'audio …