I obtained my Ph.D. in Neuroscience from Paris Descartes University in 2014 where I investigated how neuron-microglia interactions shape neuronal microcircuits during postnatal development in mouse brain in the lab of Dr. Etienne Audinat in Paris. We showed that deletion of the neuron-microglia - fractalkine-CX3CR1 - signaling pathway leads to delayed microglia recruitment at maturating synaptic sites, which coincides with delayed synaptic maturation. After my Ph.D., I focused on a deeper analysis of neuronal microcircuit activities in vivo in awake mice.
My first postdoc was in the lab of Prof. Albrecht Stroh in Mainz, Germany, where I analyzed the abnormal neuronal activity of cortical microcircuits in the very early stages of Huntington’s disease using in vivo 2P Ca2+ imaging and found that metformin treatment could prevent these changes. To integrate the knowledge that I obtained from my Ph.D. and my postdoc experience, I am now working on projects to decipher the role of neuron-astrocyte interactions on circuit activities and behaviors in the lab of Neuroglial Interactions in Cerebral Physiopathology directed by Dr. Nathalie Rouach.
I am developing various projects to determine the impact of astrocytes on brain physiological behaviors (sociability, maternal care, etc.) and in pathological contexts such as cocaine sensitization using cutting-edge technologies such as Ca2+ imaging in vivo in freely behaving mice.