Résumé
Self-assembling polymer-based nanosystems, particularly polymer micelle-type drug delivery systems (PM-DDS), have emerged as powerful platforms for the smart delivery of therapeutic agents. Constructed through the spontaneous organization of precision-engineered block copolymers, these nanoscale carriers—typically 10 to 100 nm in size, comparable to viruses—feature a core–shell structure that enables both efficient drug encapsulation and excellent biocompatibility. While initially developed for small-molecule delivery, PM-DDS technology has rapidly evolved to accommodate more complex modalities such as nucleic acid and protein therapeutics, as well as imaging contrast agents. This presentation will focus on recent advances in PM-DDS, with particular emphasis on systems designed for the delivery of nucleic acid-based drugs including siRNA, antisense oligonucleotides (ASO), and mRNA. Highlighted examples include platforms that have progressed to clinical evaluation, underscoring the translational potential of these self-assembling nanocarriers in addressing intractable diseases.
