Arnold Kriegstein est invité par l'assemblée du Collège de France sur proposition des Prs Jean-Jacques Hublin et Alain Prochiantz.
Les conférences sont en anglais.
Présentation
The human cerebral cortex is more than three times expanded compared to our closest non-human primate relatives. The cortex emerges from a pseudostratified neuroepithelium giving rise to radial glia, the neural stem cells of the cortex. Subtypes of radial glia have been identified, and technical advances have enabled the construction of multiomic molecular atlases of the human neocortex across developmental stages at cellular resolution. The results illuminate molecular and cellular dynamics of the developing human neocortex, including gene regulatory networks and lineage potential. Insights include language specializations, brain evolution, mechanisms of glioblastoma, and cell-based therapy for neurological disorders.