X-Chromosome Inactivation

Détail de la mosaïque de Tsipori (Sepphoris), « maison de Dionysos », Israël. cc0 — Detail from the mosaic at Tsipori (Sepphoris), "house of Dionysus", Israel. cc0.

Organised by: Pre Edith Heard (Collège de France, Chair of Epigenetics and Cellular Memory) and Pre Claire Rougeulle (Institut Curie)

Documents and media

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Program

Symposium

08:55 - 09:00

Introduction

Edith Heard

10 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Probing the mechanism of Xist RNA localisation in cis with live-cell super-resolution imaging

Neil Brockdorff

10 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Exploring the Role of XIST in X-Chromosome Regulation During Early Human Development

Charbel Alfeghaly

10 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Balancing the X: From Mouse X-Chromosome Upregulation to Human X-Chromosome Inactivation

Vincent Pasque

10 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

X-chromosome dynamics in Cynomolgus monkeys

Ikuhiro Okamoto

10 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Reprogramming the X-chromosome: insights from the germline

Maud Borensztein

10 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Exploring X-inactivation’s raison-d'être

Rafael Galupa

10 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

How is X-chromosome inactivation restricted to females?

Edda Schultz

10 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Inactive X chromosome erosion in TNT reprogrammed hiSPC

Marnie Blewitt

10 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Xist RNA and XCI maintenance mechanisms in female B cells

Monserrat Anguera

11 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Modulation of X chromosome inactivity and phenotypic consequences

Céline Morey

11 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Tlr7 bi-allelism defines a functionally distinct B cell subset and drives systemic autoimmunity

Jean-Charles Guery

11 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Sex bias in immunity: alteration of X-chromosome inactivation of the TLR7 locus and autoimmunity

Julie Chaumeil

11 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

Elphege Nora

11 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

EZHIP is required to maintain H3K27me3-dependant imprinting post fertilization in mice

Raphael Margueron

11 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells

Simão José Teixeira da Rocha

11 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

Closing words

Edith Heard

11 Jun 2025

X-Chromosome Inactivation

Amphithéâtre Maurice Halbwachs, Site Marcelin Berthelot

11 Jun 2025

12:40 - 13:00

Documents and media

Program

Introduction

Probing the mechanism of Xist RNA localisation in cis with live-cell super-resolution imaging

Escape from X-inactivation is directly modulated by Xist RNA levels

X-Chromosome Inactivation

The impact of sex chromosomes on the mouse preimplantation embryo

HCFC1, a novel activator of XCI

Mechanisms of sexual dimorphism in liver physiology and cancer

X-Chromosome Inactivation

Using marsupials to understand the evolution of mammalian X inactivation

Exploring the Role of XIST in X-Chromosome Regulation During Early Human Development

Balancing the X: From Mouse X-Chromosome Upregulation to Human X-Chromosome Inactivation

X-chromosome dynamics in Cynomolgus monkeys

Reprogramming the X-chromosome: insights from the germline

Exploring X-inactivation’s raison-d'être

How is X-chromosome inactivation restricted to females?

Inactive X chromosome erosion in TNT reprogrammed hiSPC

Xist RNA and XCI maintenance mechanisms in female B cells

Modulation of X chromosome inactivity and phenotypic consequences

Tlr7 bi-allelism defines a functionally distinct B cell subset and drives systemic autoimmunity

Sex bias in immunity: alteration of X-chromosome inactivation of the TLR7 locus and autoimmunity

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

EZHIP is required to maintain H3K27me3-dependant imprinting post fertilization in mice

XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells

Closing words

See also