The impact of sex chromosomes on the mouse preimplantation embryo

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Speaker(s)

Daniel Snell

Crick Institute, UK

Events

Symposium

10 Jun 2025

08:55 - 09:00

Edith Heard, Claire Rougeulle

Introduction

Probing the mechanism of Xist RNA localisation in cis with live-cell super-resolution imaging

Exploring the Role of XIST in X-Chromosome Regulation During Early Human Development

Balancing the X: From Mouse X-Chromosome Upregulation to Human X-Chromosome Inactivation

X-chromosome dynamics in Cynomolgus monkeys

Exploring X-inactivation’s raison-d'être

Reprogramming the X-chromosome: insights from the germline

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

How is X-chromosome inactivation restricted to females?

Inactive X chromosome erosion in TNT reprogrammed hiSPC

Xist RNA and XCI maintenance mechanisms in female B cells

Modulation of X chromosome inactivity and phenotypic consequences

Tlr7 bi-allelism defines a functionally distinct B cell subset&nb…

Sex bias in immunity: alteration of X-chromosome inactivation of the TLR7 locus and autoimm…

EZHIP is required to maintain H3K27me3-dependant imprinting post fertilization in mice

Simão José Teixeira da Rocha

XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells

The impact of sex chromosomes on the mouse preimplantation embryo

Speaker(s)

Daniel Snell

Events

Introduction

Probing the mechanism of Xist RNA localisation in cis with live-cell super-resolution imaging

Escape from X-inactivation is directly modulated by Xist RNA levels

X-Chromosome Inactivation

The impact of sex chromosomes on the mouse preimplantation embryo

HCFC1, a novel activator of XCI

Mechanisms of sexual dimorphism in liver physiology and cancer

X-Chromosome Inactivation

Using marsupials to understand the evolution of mammalian X inactivation

Exploring the Role of XIST in X-Chromosome Regulation During Early Human Development

Balancing the X: From Mouse X-Chromosome Upregulation to Human X-Chromosome Inactivation

X-chromosome dynamics in Cynomolgus monkeys

Exploring X-inactivation’s raison-d'être

Reprogramming the X-chromosome: insights from the germline

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

How is X-chromosome inactivation restricted to females?

Inactive X chromosome erosion in TNT reprogrammed hiSPC

Xist RNA and XCI maintenance mechanisms in female B cells

Modulation of X chromosome inactivity and phenotypic consequences

Tlr7 bi-allelism defines a functionally distinct B cell subset&nb…

Sex bias in immunity: alteration of X-chromosome inactivation of the TLR7 locus and autoimm…

EZHIP is required to maintain H3K27me3-dependant imprinting post fertilization in mice

XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells

Closing words

See also