XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells

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Speaker(s)

Simão José Teixeira da Rocha

IBB, Lisbon, Portugal

Events

Symposium

10 Jun 2025

08:55 - 09:00

Edith Heard, Claire Rougeulle

Introduction

Probing the mechanism of Xist RNA localisation in cis with live-cell super-resolution imaging

Exploring the Role of XIST in X-Chromosome Regulation During Early Human Development

Balancing the X: From Mouse X-Chromosome Upregulation to Human X-Chromosome Inactivation

X-chromosome dynamics in Cynomolgus monkeys

Reprogramming the X-chromosome: insights from the germline

Exploring X-inactivation’s raison-d'être

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

How is X-chromosome inactivation restricted to females?

Inactive X chromosome erosion in TNT reprogrammed hiSPC

Xist RNA and XCI maintenance mechanisms in female B cells

Modulation of X chromosome inactivity and phenotypic consequences

Tlr7 bi-allelism defines a functionally distinct B cell subset&nb…

Sex bias in immunity: alteration of X-chromosome inactivation of the TLR7 locus and autoimm…

EZHIP is required to maintain H3K27me3-dependant imprinting post fertilization in mice

Simão José Teixeira da Rocha

XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells

XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells

Speaker(s)

Simão José Teixeira da Rocha

Events

Introduction

Probing the mechanism of Xist RNA localisation in cis with live-cell super-resolution imaging

Escape from X-inactivation is directly modulated by Xist RNA levels

X-Chromosome Inactivation

The impact of sex chromosomes on the mouse preimplantation embryo

HCFC1, a novel activator of XCI

Mechanisms of sexual dimorphism in liver physiology and cancer

X-Chromosome Inactivation

Using marsupials to understand the evolution of mammalian X inactivation

Exploring the Role of XIST in X-Chromosome Regulation During Early Human Development

Balancing the X: From Mouse X-Chromosome Upregulation to Human X-Chromosome Inactivation

X-chromosome dynamics in Cynomolgus monkeys

Reprogramming the X-chromosome: insights from the germline

Exploring X-inactivation’s raison-d'être

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

How is X-chromosome inactivation restricted to females?

Inactive X chromosome erosion in TNT reprogrammed hiSPC

Xist RNA and XCI maintenance mechanisms in female B cells

Modulation of X chromosome inactivity and phenotypic consequences

Tlr7 bi-allelism defines a functionally distinct B cell subset&nb…

Sex bias in immunity: alteration of X-chromosome inactivation of the TLR7 locus and autoimm…

EZHIP is required to maintain H3K27me3-dependant imprinting post fertilization in mice

XIST and the Maintenance of XCI: Lessons from XCI Erosion in Human Pluripotent Stem Cells

Closing words

See also