News

How age, gender and genetics shape antibodies

Antibodies responding to the covid-19 coronavirus, illustration - dr_Microbe, Istock.

Age, biological sex and genetic heritage influence antibody production during an immune response. A team of scientists from the Institut Pasteur, CNRS and Collège de France, including Prof. Lluis Quintana-Murci, have shown that these factors modulate not only the quantity of antibodies produced, but also the precise regions of the virus to which the antibodies are directed. This discovery could have major implications for the development of treatments better adapted to individual immune responses. This work will be published in the journal Nature Immunology on February 16 2026.

Article reference

Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses, Nature Immunology, 16 February 2026.

Axel Olin, Christian Pou Anthony Jaquaniello, Jack Crook, Ziyang Tan, Maguelonne Roux, Florian Dubois, Bruno Charbit, Dang Liu, Françoise Donnadieu, Laura Garcia, Camille Lambert, Emma Bloch, Emmanuel Clave, Itauá Leston Araujo, Antoine Toubert, Maxime Rotival, Étienne Simon-Lorière, Michael White, Petter Brodin, Darragh Duffy, Lluis Quintana-Murci, Étienne Patin, on behalf of the Milieu Intérieur Consortium.