" Ultra-transformation ", " ultra-formulation " and food additives : have we gone too far ? What impact on our health ?

Food processing over the ages has led to considerable progress for mankind, in terms of microbiological safety, food security and time-saving preparation. However, the health impact of various ingredients widely used by the food industry (additives, hydrogenated oils, glucose syrup, etc.), or of contaminants created during processing or originating from packaging (plastics, mineral oils, etc.), is now a major concern. What do we know so far, and what avenues of research are ?